I'm tempted to write (or more honestly think about writing) a second-person shooting game now. Kind of like riding a bike with the steering set up in reverse.
It's been done (http://games.softpedia.com/get/Freeware-Games/Second-Person-Shooter--Missing-Inaction.shtml). Annoyingly the author seems to have purged it from his projects list, so I can't find the previous writings about it.