I'm not entirely sure what you mean. Certainly I find that if I try to do something I used to be able to do automatically but haven't done in a while, it feels unfamiliar until it comes back to me, but I'm not sure I'd describe that as "oddness": it seems obviously natural that things should work that way. I therefore suspect I'm not thinking of the same thing you are.

I mean when you learn something completely new. Do it and see if you get weird things happening with the rest of your brain. (If you have time!)

Hmm. When I learned to play Solo recently I suddenly found it really odd to look at a (say) seven-digit number which had a repeated digit; I'd got so used to ensuring that never happened that I felt a subtle wrongness if I caught sight of, say, a catalogue number on some packaging. Is that the sort of thing, or are you thinking of glitches that have no obvious relation to the new thing being learned?

Things that have no obvious relation to the new thing, sort of.